Overdose is actually highly noticeable. Painkiller overdose is hard to detect until its too late. Our whole body goes numb, you will move slowly and it will be harder to keep breathing, until, you become paralyzed and your breathing stops.
So I think in-game it should reflect this, with some messages and stat reductions. So it’s not an instant death. Maybe a (Take another painkiller, overdosing is kind of a bitch Y/N)? Thing?
But really paralysis is the final stage, if you don’t get help right then you will die. Basically your nerve endings stop firing, so you move slower. It becomes harder to move and breathe, and you slowly die of asphyxiation. Which people have attributed to be worse than guiliteened.
So yeah, overdosing on painkillers is bad mkay?