It’s kinda ironic, I don’t do drugs or alcohol in video games. I just never think to use them, very game that has drugs, you don’t really need them anyways. The most I ever did was keep about 2-3 beers in Fallout New Vegas so I could fast-travel with the slight strength bonus when I looted the crap out of some place.
IRL I’m basically high or drunk every waking moment when I’m not at work and I have 2-3 beers on my desk at all times and I don’t even need the strength bonus.