Combining gems and socketing them to weapons and armor to increase their power. An average player should wear about 48 clothing gems, 4 per each of 12 units of clothing. Each gemology level should give you a change to remove gems, combine gems of equal rank to raise their levels, and reinsert them. And while we’re at it, let’s socket NPC equipment too at higher levels.
A dominatrix scenario where you start with positive morale in a basement. An NPC starts out next to you, but stuck in place until you find and bring a knife over.
Krocodil, an expecially addictive painkiller that does severe damage to your arms when you use it. Also lowers your health enough to instantly give you a cold.