Failed brain-related CBM installs (Enhanced Memory Banks, Synaptic Accelerator, etc etc) have a chance to instantly kill you due to brain damage.
High-recoil weapons can damage weaker characters trying to fire them when the gun smacks them in the face/breaks their shoulder.
‘Blind’ trait: character is permanently blind, also meaning they cannot tell what is in bottles/cans/boxes except by touching/tasting.
‘Crippling Osteoporosis’ trait: character has 99% less HP. Not accurate depiction of the disease, but could be fun for a challenge run.
Asthmatic characters suffer constant asthma attacks when suffering from smoke inhalation.
Zombie Hulks throw cars.
Manhack Head CBM which replaces your head with a heavily-armoured, detachable controllable manhack. For surveillance!