I heard a bit going around a while back that the blob was already everywhere; in the water supply, in the wildlife, and, of course, in people. I don’t know whether it’s accurate, but it could be the basis of a “kill all instances of the blob” prime directive backfiring, and causing the AI to turn against everything, because it detects blob in everything. This could justify having very advanced technology on the AI, because the only entities that would know the blob exists, let alone know enough about it to program a machine to target it, would be XEDRA, and other large military installations.
I saw an entry somewhere, I think it was a lab computer, where one of the executives in the labs issued an order for the scientists to carry around bottled water, because they discovered that the blob was in the water supply. This implies that it began pervading at least the laboratory, before most people were aware of it, so it is possible that an AI could have been made to target it before it was well-known that it was already everywhere.
Thoughts?
Edit: It was already everywhere before the Cataclysm, that is.