On tip you might already know about, is the option “Force Y/N” in prompts. If you set it to false, you can just hit (y) and (n) without needing to hit (shift) first.
What I do when I harvest dandelions in the wild, is after I hit (e)xamine and the direction of the bush/plant, I hit the direction again, which changes the prompt from (y) to (n), and then enter on my numpad. So it’s a real quick sequence of buttons that you get the hang of by just double clicking the direction of the plant with your movement key, instead of the single click you would normally do, before getting to the Y/N prompt.
I have every item you can find in the wild, just about, on my auto pickup list, but if I don’t I just hit (0) on my numberpad, which is the same as (,) I just added a 2nd key bind so I don’t have to really lift my hand off the number pad or move my left hand from (e) to (,). If it’s just one item, hitting (,) or (0) will pick it up, if it’s more than one type of item you just double tap (,) or (0) then enter, to grab it all.
Example; If a row of plants is east of me I do, (e)+(6)+(6)+(Enter)+6, then your standing in front of the next one, and repeat.
You can hit any button to get it to change form Y to N, not just the directional buttons, but you will need to still hit enter after, unlike when using (Y) or (N).