Help with custom Profession creation

When creating a custom profession, how does one make it so that profession starts off with a permanent debuff like teleglow or something? What about a curse debuff like ‘always bad weather’?

And is it possible to start that profession off with an Artifact?

I’m totally clueless on adding anything other than INFECTED and that would be a scenario flag.
Now…you could figure out how the monomolecular blade becomes irremovable if you spawn one in and wield it, create an artifact with that property and bad weather plus whatever and add it to the equipped items they start with. I don’t know how you’d go about creating a random artifact on creation though…

Right? Its tricky, they have flags for infected starts, but why not flags for starts with the other debuffs or whatnot.