All players, NPCS will constatly deplete in Head, Torso, and Arms until death when stats through skills is enabled. This applies even with debug invincibility applied to players or NPCs.
In addition, this depletion will “infect” any other world or save loaded, even if that world doesn’t have statsthroughskills enabled in that session. Restarting, and loading a save without that mod doesn’t reapply it until stars through skills is enabled again.