Good question: I’m also thinking of adding a “strange map” to any of the arcana locations, considering how they’re usually hard to find and flesh out the rewards a bit more (mostly books and other magical items) considering just how powerful the monsters are with PK enabled (last time I got near one I saw a bloody shoggoth, I’m removing that one from the premises, nobody should ever encounter a PK shoggoth in the overworld)
I usually start with the strange grove by torching it from afar before even getting near, then use the map inside to try and raid all the ruins for their sweet books. I’m not particularly interested in the arcana drops other than the most mundane ones I can fabricate myself like the hammer of the and other junk, but some of the endgame ones like the restored ritual blade are really nifty. For most of the time, I try to simply get in and out as fast as I can to grab the books I’ll need.
If you mean in general, the best way to go is jabberwock(x2), then megabear, then fungal, then ant, then triffid, then blob (don’t try to kill the shoggoths) and only finally once you know you can take a couple plasma rockets to the face if you aren’t fast enough: Spider Mastermind.
Blob is particularly nasty, but there’s a hidden reward in the slime if you manage to find it that is on-par with the spider mastermind treasure.
Anyway, back to work work work.