Don’t know if they are simple or not… 
Challenge: You Are The Bear
Something changed. The smell… the taste of water… something else is around now. And also, these pesky creatures, carrying stuff around and invading your territory like it’s nothing! Time to defend it of them and WHATEVER ELSE!
Starts as a Bear, in the forest or close to a city OR EVEN BETTER, close of a evac shelter, complete with a window to jump and a survivor to attack! Complete with mutations to simulate it in the top of a Human template - Can’t use clothes, can’t speak, can’t use items as a human would, only do noises, and other bears don’t like you.
Challenge: You Are The Monster
By bad luck, you became a “volunteer” to experiments. You don’t remember how long they injected stuff at you… changing you… changing you back… then, too much changes. Locked in other cell, a different cell, being studied to a point everything else is a blank. Surviving was the only thing in your mind…
…and still is. Food is gone. They are all gone. Guided by lingering memories, to leave the cell, find nourishment and perhaps… a way to find the meaning of that three-letter word.
Starts as a post-threshold human critter, with options in the Jobs tab to which one. Have dreams of being a human, starts in the last floor of a underground lab, in a special room, for good study material cases.