Is it possible to have the game react to mouse clicks?
The game already reacts to mouse clicks, just try double clicking on a tile and your character will move there. If you instead mean allowing the menus of the game to be controlled by the mouse, then that is something which would not really be achievable with a mod. It would be the kind of thing that would require actual coding and would be far more likely to get pushed onto git hub than be a mod. I’m not even sure mod files would even allow for that sort of thing.