I got infected by fungaloids for the first time, I went to sleep, woke up with heavily damaged arms, kept going for a while. Eventually, fungal tendrils sprouted out of my hands and brought both my arms to 0hp. That supposedly didn’t stop me from cooking some meat, downing some drugs, and go beat(taekwondo) on a horde of zombies before stepping on a landmine and as a last resort using dynamite to break into a bunker to have a safe place to recuperate, turrets got me.
Until the end though, it seemed I still had functional arms, they never blocked hits, only my legs did, but somehow I was still jabbing stuff. I even managed to beat a wolf to death with a nutritional cybernetic i had picked up along the way.