I leave it to true because it takes more than one keypress, but I also turn off other options like querying on disassemble and auto-safe mode and other things that would cause prompts to appear. Generally I play very deliberately and I also type very quickly, so pressing keys is by far the minority of my time in game, except for movement and loot sorting.
The only time prompts come into play is when there might be some kind of danger around, in which case I want them to be slightly more difficult to randomly press if, for example, a cat runs across my keyboard for no apparent reason, he probably isn’t going to hit Shift+Y, but he will definitely hit y by itself.