Every once in the while, I play as an overpowered character (high stats, high skills, high tier equipment, almost all of bios except for internal weapons, almost all positive mutations plus Prototype threshold) for a bit of mindless fun.
Which ends as soon as I get blown up, crashing me to desktop.
My amateur guess is that there are too many calculations related to the interactions between explosions, bionics and mutations going on for the game to handle.
Highly unlikely for normal characters to reach a point with bios and muts for this to matter, but just a heads ups.