Some possible causes:
Repairs are no longer instant and nearly free. If you feel forced to always have reinforced items, that could get tedious. I’m trying to address it by making reinforcement less required (by making it less useful) and repairs easier and faster.
There are some issues with the magazine and holster system, mostly extra prompts and having to reload every magazine manually. They’re being addressed, soon we’ll probably be back to reloading with just ‘r’, as before.
Item volumes are now rounded up rather than down. This means more thoughtful and less cheesy inventory management. Not everyone likes inventory management, as it is an inherently tedious mechanic.
Encumbrance system is way, way less cheesy. No 2bindle+2briefcase+2basket etc. melee combatants.
Being immune to acid zombies isn’t trivial. In stable 0.C, you could just ignore them and let them melt corpses.
Unarmed melee combat is no longer better than fire axes (at least early on). If you relied on fists, you no longer have amazing armor-piercing crits.
Armed combat got balanced. Best options got nerfed, mediocre options got buffed. If you rely on overpowered weapons or overpowered styles (Niten), you now need to attack more to get the same effect as before.
Having to find magazines to weapons means you’re significantly less likely to get working guns early on. Except shotguns - those are common and usually need no magazines.
The game got harder in general. Difficulty has an element of tedium to it, since you need to be more careful.
