Cripple - Spawn a bear trap to take off one of your legs. Proceed to survive. Delete the bear trap from existence.
Dark Ages - No technology, cars, electronics or anything more modern that Renaissance period (if in doubt don’t use it)
Dark Ages (harder) - Same as Dark Ages, but spawn in a broadsword (or other similar melee) and if there is a suit of armor wear that.
Recovering Addict - Use no drugs. First aid and bandages and aspirin are OK, aspirin is not allowed for a harder challenge.
Pyro - After leaving a building for the first time (also the last) burn it. You can have a base of operations on easier difficulties.
Pyromaniac - After leaving a building burn it. You can not have a base of operations, unless it is an inflammable car.
Fashion-ista - Only wear one piece of clothing on any body part (no stacking). Having different parts singly layered is OK. Duel covering objects (blankets and others) are OK, as long as they are the only thing on that part of the body.
Devout - Survive in a church or cathedral. Must wait for between 30-60 minutes a day at one of the benches.
Pacifist - Never kill anything, Z’s included. Most town runs will become grab-runs, and you will survive in the wilderness.
Purifier - Kill every non-natural beast. These include all moving things except: NPCs, rabbits, squirrels, fox, wolves, deer, cougars, mousse (Or whatever plural of moose is), cats, dogs.
Desert Punk - Wield a Winchester, always drink water (nothing else), kill all male NPCs and try to befriend all female NPCs.
Politician - Wander the world learning speech and barter. Befriend as many NPCs as possible, and try to keep then alive. If somebody disagrees with you promptly give them a few bullets, preferably in the head.