Static NPCs are perfectly fine in that department in my experience. Random NPCs used to cause crashes for me but that’s been rectified (their heads explode to avoid shit like infinitely trying to eat a lighter and thus cause a crash) other then that they’re in a pretty non-buggy state. Though bandits don’t seem to be automatically hostile/register as such recently. So you can’t preemptively attack without suffering a ‘killed an innocent’ morale penalty.