The first time I tried Android perk I started with Fusion Blaster arm and Metabolic Interchange.
It was almost too easy. I could simply walk around blasting everything with impunity, occasionally retreating for a snack.
(I ended up dying while off-roading in my motorcycle, hitting a land mine, and then getting surrounded by worms. Probably could have made it out but I was a little overconfident.)
The arm uses rifle skill and can do hundreds of damage when it scores a headshot. I took down quite a few zombie hulks with only 2-3 blasts. Being unable to equip anything larger than a handgun was irrelevant.
HOWEVER, it also limits your ability to carry large objects in your hands, I think. For example I couldn’t carry a big tire around anymore, I seem to recall. But overall, still worth it, if you can power the thing. It uses 2 power per blast.