When I was playing back in the day… probably two years ago, the game didn’t feel so balanced unless I took the Fragile trait. It no longer feels needed. Not sure if the game was rebalanced, or if I just got really, really bad at this game. Prepare to die many many times.
Biggest things I can think of are the introduction of stamina. Fighting will consume it and slow you down if you use too much. you can use " to sprint, however if you sprint too long you’ll be like twice as slow as walking. So be careful with that. Can save your life but if you forget to turn it off it will cost your life.
Guns have an aiming system, when you go to shoot take a look at all your options, maybe experiment on harmless animals to get a feel for how long aiming takes.
Also guns have clips. Its weird, but useful in saving time in a fight. Use them.
The encumbrance system changed. I think 1 encumbrance in the old days is 10 now. Otherwise it works the same I believe.
And weather will kick your ass if not prepared. Dress appropriately.
Those are some of major things I can think of that I had issues with when I first encountered them.