Antiseptic bottle can be used even when it contained antiseptic hit 0. Bottle will disappear after leaving game.
For this to be a useful bug report, more information is needed. What version are you playing, exactly. Which platform are you on? Are you running any mods? And lastly, can you upload a save that this bug is reproducible in?
The New Issue button here will bring you to a page with a template for a proper bug report: https://github.com/CleverRaven/Cataclysm-DDA/issues
Nice one! Looks like they already got it fixed, too.
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