Just as an update:
Upgraded my game from 8050 to 8083, Windows Graphical edition. loaded up my savegame from 8050, where i already had some fun, even changed the weather to rain, just to see if any issues show up: Nothing at all. Game seems to run very smoothly, barely uses any CPU and not even 1gb of RAM. Keep in mind, I have a heavily modded game, with 49 mods of varying sizes and I’m using the MSX+ Dead People Edition Tileset, so those numbers could actually be lower, depending on Tileset and mod usage.