So I pplied a glass pipe and chose to smoke weed from the menu.
It tells me "you smoke some weed, good stuff man!"
It does give odd messages like “Dave’s not here, man” and “Could Jesus microwave a burrito so hot that he himself couldn’t eat it?”
But no “depressants” in the ‘@’ screen, and no “enjoyed weed” in the ‘v’ tab, like when smoking a joint.
EDIT: it does however incur stat penalties.