Fair enough. Like I said, all of my input is anecdotal or educated guesses.
There was a discussion recently – Spawning items on rotated tiles in which the room orientation was affecting the location of spawned items. This was for missions. Presumably, a non-rotated location makes it much easier.
I personally can’t think of any other reason to turn off rotation. Unless, say, you made your location in the shape of a smiley face or something that you wanted people to notice immediately. In the case of the LMOE, I don’t know why it isn’t able to be rotated.