I brought this up in a thread about having conditions like broken bones, but wouldn’t it be possible to install a disease that gives a minimum threshold for pain? If you are below that threshold, it procs the pain up to the given level, so that you are never below that amount. Painkillers could nullify it for a while, but it could come back if the cause isn’t treated, and perhaps escalate into something worse.
You could use this for a lot of different things to emulate many different conditions. For instance, getting stung by a giant bee? That would suck. Technically that should probably kill a person, but at the very least whatever you got stung in would ache like a bitch. You could also emulate broken bones like this - put a cap on the HP of that particular limb to emulate the severity of that break and put a minimum pain level on it based on how bad it is. If it’s completely shattered (ie ‘broken’ currently) it hurts quite a bit and the limb is utterly unusable. A fracture could probably be healed naturally without any kind of treatment but it’d still hurt for a little while.
This could also be used to emulate bruising, stomach aches, and things that really just should hurt a bit longer than they do. A shattered leg should ALWAYS hurt and should never fall to zero just because it’s been a while for the pain to die down.
Painkillers and the like would also increase in value because of this. Currently there’s no reason to take them just because the pain will fall all on its own. It’s also a bit more realistic this way.