Using different gunpowder types/amounts in the same clip and then going full auto may well cause all sorts of problems, I can’t say I know for sure, but probably would only result in more frequent jamming at worst if the gun was rated for all the ammo being used. (long as its strong enough to push back the reloading mechanism, but not so strong as to cause the gun problems) In addition to this it would throw your aim off TERRIBLY at longer ranges, as the arcs the bullets follow would be very different, and you can only have your scope/sights set for one (at a certain distance(s) (on the way up and the way down)
That said, if you only mean different tips (FMJ, Balistic tip, soft point, split tip, etc…) the effects would be minimal only effecting the ballance/ mass of the bullet. (which would still have an effect on accuracy compared to what it is sighted in for) but at smaller distances would not be enough to cause any issues.
I know people who (when hunting pigs) do FMJ’s for the first 1-3 in their clip and then Balistic tips because they often get multiple lined up for the first shot, and want the extra penetration for going clean through the first (and secound?) pig(s) and then there are pigs going everywhere and they want as much; hydrostatic shock, rapid dispersion of energy etc… for more killing power, and knockdown power respectively where they are shooting at bodies running everywhere.
I also know people who load full FMJ and then a few Balistic on top, because after the first shot(s) pigs are just running everywhere and its kind of hit/miss and FMJ are cheaper rounds.