Yes, Cata is very creative in planning the deaths of survivors.
Ahem, whilst you might know this already, it is still important to note that your torso should not be encumbered more than one or two points. Anything above that will sharply reduce your char’s ability to dodge, which sucks if you are fighting anything that won’t go down in one hit.
So if you see an enemy, drop your backpack and (almost) everything you have on you and then go fight it. Now, there are certain places in Cataclysm which… are very dangerous. Like swamps, and hence if there is a swamp in a three map tile radius of you, the most logical thing would be to pack your bags and run somewhere else. Also avoid beehives, triffidgroves, and fungaloids. Fungaloids, whilst easy to kill at first, will reproduce so much that soon you will be fighting hundreds.
With the enemies out of the way, it would be wise to find a car lot and grab a motorcycle or anything except a bicycle or a truck. Bicycles are a quick way to help one dying especially if one is running away from something that is faster than a turtle, and trucks make noise which will help attract dozens or hundreds of zombies whilst wandering around in a town.
Oh and if you wish to kill a horde of zombies that are following you around, it would be necessary to find a 1x1 window, break it and crawl into the room behind it, and wait for the zombies to pass through it so that you can stab\hit\squash\punch them to death one-by-one.
Tl;dr: Avoid beehives, triffidgroves, swamps, and fungaloids like the plague. Find a vehicle that isn’t a bicycle to help you run away if things get too bad, and never fight whilst encumbered. Also, if you are fighting against zombies, find a 1x1 window and lure the zombies through it to kill them.
Ahem, as in DF, losing (dying, actually) is FUN! Good luck surviving.