Very nice idea. Addictions are nice roleplay elements and can have some pretty serious symptoms while in withdrawal. I usually wait out addictions as soon as I get them so I have very little actual playtime with severe withdrawal.
To add to this how about the ability to start with:
-high on drugs (for tweakers)
Starting with short and long term negative effects in cities is fairly seriously challenging. RBD challenge is fun for me, but a way to mix and match the challenge would be nice.