Well, personally, my most successful character to date (having recently ‘celebrated’ her second year in the Cataclysm starting) was:
Str - 10
Dex - 8
Int - 14
Per - 10
Animal Empathy, Fleet-Footed, Less Sleep, Night Vision, Quick
Addictive Personality, Glass Jaw, Heavy Sleeper, Insomniac, Poor Hearing, Weak Stomach
Started as a Lost submissive with no skills.
And at this point she has a mobile fortress with laser cannons on it, a few years worth of clean water, a few decades worth of preserved food, and is working on moving into a recently found farm to ensure a steady supply of fresh food for life.
Oh, and she has mutated a ton, but lucked into good gene mutation almost right away. So between that and some tactical switching of what mutagen she uses, she has a slew of good mutations and only a couple of bad ones. Also lots of cybernetics thanks to high int.
Started with her making a sling, then a slingshot fairly early. Used that for a bit till she could craft a proper bow. Took ages to get up to a reflex recurve bow and metal arrows, but when she did, all things fell before her.
About the only thing she wants for at the moment is a medical serum so she can evolve into her proper form.
I’m sure I should have gotten things like masochist for her for story reasons, but I hadn’t made a character last past about 2-3 days before this, so I was already somewhat crazy going with a negative profession and didn’t want to use up points on something I didn’t think would be so useful, but it all ended up working out quite nicely.