S is used to save the game, fairly common to use it that way as save is more common in most games then safemode, nice quick method to do so, your changing of the keys makes it take more presses to save the game, I guess just so people can bumble into safe mode trying to save a game and not know they did it and die. Even knowing about safemode takes reading up on the controls.
Changing read, and run fixes nothing except now new players having to look up how to read, or even knowing they can do it that way instead of multiple key presses to open inventory, select the book, and choose read that way.
Opening a curtained window, and interacting with it is different, changing open and close would add more key presses when doing so for the entire game, just for the sake of people not having to read as much to learn the controls at first.
Changing chat and craft I see nothing wrong with, but no benefit to it either, same issue for new people they wouldn’t know how to talk to NPCs, (and that can be deadly) with out reading about the controls
It is easy enough to change the keybindings yourself for your game. Personally anytime I start playing a new game I look over the keybindings to see if I want something different.
To me none of these changes would address the issue of new players not knowing all the controls with out looking them up, so why take the time to make the change? But others might like it, if you want to take the time, code it up and submit it on github, see how it is received.
