I really love what Chezzo said about loving a charicter that reads comic books. I remember playing dwarf fortress and ending up loving some of the quirkier charicters. I know if i ran across an otaku girl in a cat costume hiding in a closet, Protecting her would be a new goal for me.
Dwarf fortress shows us that in the random generation of the game we can have amazing adventures when quirky things happen. That it is someones (NPC) idiosyncrasies that we end up loving. making art around, and making comics about.
I’d love this game to have more of this. this is split between the map gen and the NPC generator. in the map gen i’d love for their to be “special interest sites” for new towns. where a few leader charicters can be run across. each season the leader charicter adds more guards and more defenses to his faction base. by second summer we would stumble across a town that had 6 seasons of growth.
that can be randomly generated.
John Candlebury’s idea of a respawnable tag is great too. but i’d like it to be bigger than his idea. I’d love groups to create trade caravans that travel from one city to another. this would be 2nd or 3rd summer events.
I really want each grouping of city to be named and have a few signs saying “tacoma’s favorite tea shop” “welcome to beetsville” then have npc’s refrence these town names. or tell you “its 2 miles north of Beetsville, in Slumsmuck”
I’d really like npc’s to tell you “I heard about a new town thats starting in the north. its run by Cockswain. I’m going their now.” or “Stay away from east tacoma, Theirs a biker gang leader taking over the area with a group of lawless men, You’ll get shot going over there.”
It would give me some places to go trade/loot.
I make my own objectives but If i find a group of slavers in the game, you bet your bones i’m going to try to wipe them out.
Thats a fun adventure 
In npc map gen i’d love to see the mall/hospital have a pile of npc’s in it to start. do I help the weak vs. the strong.
I do enjoy seeing the npc’s when they are a few blocks away on the mini map. thats great. what about monsters and fog/acid rain clouds.
yeah thats all for now. see ya after i figure out why my npc keeps blowing up just by walking a few squares.