I have experienced multiple problems when it comes to loading artifacts, whether having them on my character or not.
At one point I experienced the failure of my very long save game due to the fact that I autosaved, rather than saving to quit, after an artifact was spawned in-world.
Personally, I think it would be nice to be able to toggle artifact generation in-world on and off in the options menu, as a solid 90% of my interactions with artifacts have contributed to character death or general harm.
Some games, it’s fun to screw around with randomly-generated mystical items, but other games, it might be nicer to have one specific deathtrap within the game removed entirely.