CBMS:
Most cbms become common enough late game that you shouldn’t feel bad loosing a few. Common cbms are anything you find in normal cbm rooms in labs. If you destroy an integrated toolset or an internal furnace there’s going to be several more just like it when you explore the next lab. Resist the urge to install the rare ones until you actually have the skills. One exceptions is that the cerebral enhancement cbm which is how you will get those insane skills to begin with. That said you should just recklessly install power storage from almost day one. Drugs can boost your int by insane amounts so use all the relevant drugs that you have in your inventory which will give int boosts. You can also get “elated” from using anything that improves your mood such as an mp3 player. Put everything together and you should easily be able to get +10. With some work you can even get to an over stimulated state where you have +20 to int.
Auto Pickup
Leverage auto pickups for all your item needs. Use ?, 3 to set up wild cards like “cash card*”. Set up a rule for every kind of 0 volume medicine. If you need batteries, power converters, etc., set up a rule for those too. Even if it’s something rare, like let’s say you are trying to build laser turrets, just set up a “laser” rule to auto pickup any laser stuff. This will save you from not noticing items when you are butchering zombies. When you first start the game everything is new, but after you have played for a while it’s easy to miss a screwdriver or other basic item because your last character already had a dozen kicking around, but your current character has none.
Get the hang of Labs
Labs are awesome. They are literally a gold mine of all the stuff you want. So get the hang of them. Even with no skills or good supplies, once you get the hang of them, you should never get killed the random turrets and other dangers. If you take lab challenge you even get extra character creation points and can start with high night vision! Also, getting out of labs is trivial once you get the hang of it.
Don’t be Ashamed
Don’t let other players shame you out of optimizing your character creation. If you are the kind of person who doesn’t like maxing out their negative traits with all the usual stuff then more power to you. However for the rest of us, please don’t feel bad for making your characters start out as awesome as possible. After all this IS the optimization problem that the game has given you.