If you’re asking about turning off all non-wildlife creatures, there’s a mod for that in the Blacklist section. ‘No Monsters’ mod.
As for no items, I don’t think such a thing exists, but you could start with the wilderness scenario and just never go to town or craft anything you don’t feel should exist in your game. There may not be mods catering to what you want, but you’re still free to roleplay and decide for yourself what your character can and can’t utilize.
Personally, I think that it’s entirely too easy to survive fully in the wilderness. I also find it very, very boring.
There are other, more appropriate threads around here somewhere discussing wilderness survival, which you might be interested in. I’m too lazy to link.