My present game is a lab-trapped unwilling mutant. Began with ursine vision to make lab exploration easier, took robust genetics, fencing, tentacle arms, and pretty good stats. Melee ability started out pretty powerful (with a cudgel) but was not finding any food in the lab, so decided to escape ASAP. From grim experience I decided NOT to mess with mutagen until I had the supplies and skill to make my own purifier. Luckily found glasses pretty early on in the lab for day vision. Spent a few hours tearing apart rags for thread, then built myself a homewrecker. Snuck around the entrance turret in darkness and thankfully was able to bash through a side room and then outside without getting spotted or shot at. Crawled out into the real world nearly naked, freezing, starving, and thirsty.
Didn’t take long to procure food…with my melee ability was pretty easy to fend off the hordes. Had a few issues when I built a forged sword only to have it stick into anything and everything. Also my first attempts at vehicle craft failed miserably due to some sort of battery power leak…security system, damaged battery, or something like that. Eventually went with a gasoline-based car with the idea of powering all my tools from it. Spent a while in town…completely armored the car, added some turrets swiped from an armored personnel carrier, replaced the trunks with cargo carrier. Filled the car to the brim with tools, food, and supplies.
At present: Have raided several towns, built up most skills to level 7+, hit several labs, a couple military bunkers. Have a whole suite of bionics. Decided to try and go spider - have a couple decent spider mutations without any negatives thanks to robust genetics, purifier, and a lot of supplies. Just found a refugee shelter and finishing off my initial quests. A couple survivor-zombie filled basements and some decent tailoring have me pretty set up with survivor gear.
Only a couple really close calls: The hand encumbrance makes reloading a pain. Discovered just how painful once when trying to take down a shocker brute. Ended up not going so well. Another time - got cocky with my armor and tried to hack down an SMG-brandishing NPC with my sword. Took longer than expected due to lots of pain, and the bastard managed to shoot one of my arms to pulp. Finished drugged to my gills with half a bar of torso health. On the other hand, picked up over 100 rounds of 9mm ammo from it, which lasted me a fair while.