There’s the occasional interesting screwup (like when all the bushes in my world turned into stained glass windows) but they’re pretty rare. normally you can just keep updating the version while running the same world.
On mutation, I like to make up a jerry can of (flavoured) mutagen and a jug of purifier. Then I sip mutagen until I get something bad, sip purifier until that goes away, then go back to sipping mutagen…
It’s slow but sure. The key is to scrub out bad mutations as soon as they arise, because the later you leave it and the more positive mutations you have the harder it is to get rid of the bad ones. Plus a negative mutation that “doesn’t seem that bad” so you keep going can then chain into a much worse version leaving you to do heavy purifying.
I don’t use serums much, because granting multiple mutations at once means you have less control. Plus the pain/hunger effects.[/quote]
OK, so I need to add those mutation-effects to orals too. makes note FWIW the conduct you describe is pretty much the intended conduct for addiction: lotsa doses at one go. Serum is stronger, true, but you aren’t rolling as often.