Similar happened to me once in 0.B.
Because of a Reptilian Muzzle mutation, i was unable to protect the character’s mouth against the cold. After got Chemical Imbalance i purified the mutations, but stuck with the Chilly (Rising!) status for 11 days. With some clothes i got the warm status, but never comfortable.
On 11. day got Chemical Imbalance again, chilly changed to very cold, but after i purified the Chemical Imbalance the body temperature changed back to comfortable.