A hard-to-reproduce bug of some sort, I think. Once all of the NPCs in the refugee center disappeared on me. But that happened only that one time among the dozens of times I’ve played.
The quest marker, in turn, never moves after it’s set once. I learned this by tracking a Jabberwock in the game - the marker will stick to that one map square but the Jabberwock can run fast away and go after other animals.