Make a knife spear on day 1, smash up a locker, a bench, and tear off a curtain off the window for sheets, get a sharp rock and cut it up. Go out to the forest and forage bushes for food (wild vegetables) and get your survival level to 1.
Once that happens, you can make a knife spear (press f to use reach attacks) and kite enemies through bushes and empty windows (Or just run around them with " ). If you’re careful and patient, you can thin out hordes by killing them one by one, I did it on a “hospital patient” run which had a net total of -75% less health than your regular character, which survived till end game.
Put points into dodge on character creation, level 3 will help you a lot. It’s normally not recommended to spend points on skills, but since it gives a leg-up for new players you might as well do it.
If you really want to go a bit overboard, pick venom mob protege, and tag scorpion kung fu, add 3 dodge, melee and unarmed and you can take care of most enemies.
My guide here if you need any extra help.
Edit: Also, try and find/make a funnel and place empty containers under it so you can collect rainwater.