As far as min-maxing goes, trigger happy is generally a free point since there are a lot of ways to never have to use an automatic weapon. Addictive personality is another thing where you can avoid its trigger. Animal discord isn’t that much of a drawback since I find there are rarely times when it seems to tip things aginst me. Same with Truth Teller, since I find lies to be a good way to go nowhere. Squeamish is the same way. I actually find heavy sleeper to be a benefit since I like to sleep on the second floor of buildings (not so much for the z-axis, since I like turning it on) since if I get ambushed there, sleeping through getting ripped apart is probably a bonus.
Hoarder I sometimes take since I find that I am a hoarder so I don’t have to worry about it as much. If its really a concern, you can just go without wearing any packs so you got a volume of 2.70 or something.
As far as for legit play, I do like Albino since it adds some character. Sometimes topofraphagnosia, combined with Forgetful, Savant, and Truth-teller I combine for a Mr. Bean build, where I bumble around doing mundane things, unaware of the apocalypse.