The most fun way to play is addled with some kind of drug. Start as a hobo, crackhead or whatever and never go cold turkey. Embrace your addiction.
I like to play a hobo with highish strength and Drunken Master. My last hobo had a strict hobo conduct - he would rely mostly on melee and be rubbish with a gun if he tried to use one, use only hobo-appropriate clothes and weapons, etc. No tacticool stuff, no bionics. Nail board, pipe, chunk of rebar or something similarly makeshift for a weapon. Hobo drunken masters are surprisingly strong, but taking enough drugs to offset the massive accumulation of depressant penalty from the hooch is difficult.
Edit: you’ll want addictive personality, as well.
